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Chicken artichoke casserole on a white plate

Creamy Chicken Artichoke Casserole

Our creamy, cheesy Chicken Artichoke Casserole is a deliciously easy baked casserole recipe you can make in under 40 minutes!
Course Main Dish
Cuisine American
Keyword artichokes, chicken and artichoke casserole, chicken artichoke casserole
Prep Time 5 minutes
Cook Time 35 minutes
Total Time 40 minutes
Servings 4 servings
Calories 780kcal
Author Isabel Laessig


  • 9 x 13 inch baking dish


  • 1 can artichokes, water packed 14 ounces
  • ¾ cup Parmesan cheese
  • ¾ cup mayonnaise
  • 1 teaspoon garlic powder
  • ½ teaspoon Italian seasoning
  • 1 cup shredded cheddar or Monterey Jack cheese
  • ¼ teaspoon crushed red pepper
  • ½ teaspoons salt
  • 4 boneless chicken breasts approximately 4 ounces each


  • Preheat oven to 375°F. In a medium bowl, combine the artichokes, Parmesan cheese, mayonnaise, garlic powder, Italian seasoning, salt, and crushed red pepper.
    Artichoke mixture in bowl
  • Place chicken in a greased 9x13 inch baking dish. Spread with artichoke mixture.
    Chicken covered with artichoke mixture in glass baing dish
  • Sprinkle evenly with the shredded cheese.
    Chicken sprinkled with cheese in baking dish
  • Bake, uncovered, for 30-35 minutes or until chicken is cooked and cheese is bubbling.
    Baked chicken artichoke casserole in glass dish


This is a gluten-free, low carb dish that is perfect for a family dinner or serving a crowd.


Calories: 780kcal | Carbohydrates: 7g | Protein: 39g | Fat: 65g | Saturated Fat: 18g | Trans Fat: 1g | Cholesterol: 132mg | Sodium: 1483mg | Potassium: 317mg | Fiber: 2g | Sugar: 2g | Vitamin A: 1582IU | Vitamin C: 21mg | Calcium: 466mg | Iron: 2mg